Endocrine Abstracts

Objective: There are many suggestions of predispositions to goiter in women with benign and malignant masthopaty, we looked for BRCA1 mutations in women wit and without goiterMethods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood samples for BRCA1 were taken, ex05 - p.Cys61Gly; ex 11 polymorphisms K1183R, mutations:...

Introduction: Neuroendocrine cancer of the ampulla of Vater area belongs to the most rare GEP-neuroendocrine tumors (NET). In the literature, there are few reports of extremely malignant course of this cancer. Among 242 patients with NET from the Department of Endocrinology in 2009–2013, 58 pancreatic NET were discovered, among which seven patients had neuroendocrine cancer of the ampulla of Vater. The aim of this study was to determine the clinical characteristics, stagi...

Introduction: Acne vulgaris is the most common skin disorder, which may be sometimes the only early clinical manifestation of hyperandrogenemia. Main role in its pathogenesis play: genetical predisposition as well as hormonal and environmental disturbances, which may begin in puberty. It has been widely discussed at what age and what kind of diagnostics should be performed in this area.Aim of the study: Was to evaluate concentrations of selected hormones...

Turner syndrome (TS), resulting from complete or partial loss of X chromosome, occurs in 1 per 2000-2500 liveborn female neonates. Most patients with TS, especially those untreated with growth hormone, present with osteoporosis or osteopenia, and are at increased risk of bone fractures. Available evidence suggests that depletion of bone mass may be associated with inadequate level of physical activity, and consequently, with too low muscle mass and strength. The aim of the stu...

Objective: Among women over 40 the prevalence of goiter in Poland is over 40% and the prevalence of vitamin D deficiency is over 80%. There have not been any previous studies that investigate the vitamin D level in women with and without goiter.Methods: 152 women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood samples for 25-(OH) D total were taken....

52 years old man medicated with amiodaron 12 months, with laboratory confirmed hyperthyroidism, in us-examination 45 ml Basedow goiter, TRAb positive; ventricular tachycardia 180/min intermittent with sinusal tachycardia 120/min, thiamasol 120 mg i.v./daily, hydrocortisone 400 i.v. daily, crystalloids, beta blockers, diazepam, albumin. J131 scintigraphy – no iodine uptake. natriumperchlorate 1500 mg daily initially, continued next month 900 mg coused iodine uptake 17%. Fi...

Introduction: Despite recommendations neuroendocrine tumors may still pose diagnostic and therapeutic problems. Patients are referred to specialized centers when their disease has already progressed to generalized stage.Case report: A 64-year old male patient was referred to the Department of Endocrinology at the Pomeranian Medical University in 2013 because of liver metastases. His medical history included a surgical treatment of left lung tumor in 2006...

Objectives: Glucocorticoids (GCs) intervene in different physiological activities in almost all systems of the human organism. However, GCs are also potent inducers of apoptosis in many cell types and tissues. It is known, that glucocorticoid-induced apoptosis affects the musculoskeletal system, circulatory system, nervous system, endocrine system, reproductive system, and the immune system. Nevertheless, the exact mechanisms of GCs action in human normal hematopoiesis are sti...

Background: Osteoprotegerin (OPG), a component of the RANKL/RANK/OPG pathway, can inhibit bone resorption by affecting osteoclastogenesis. Estrogens deficiency is associated with decreased expression of OPG and increased osteoclast activity, and thus can lead to disorders of bone remodeling.Objective: To analyze relationship between serum OPG and bone mineral density (BMD) in patients with Turner syndrome (TS) subjected to estroprogestagen (EP) treatment...

Introduction/objective: To evaluate the effects of estroprogestagen therapy (EP) on the mineral bone density (BMD) of girls with functional hypothalamic amenorrhea (FHA).Design: Prospective observation of 78 FHA girls subjected to 4-year EP therapy (Group A) and 50 controls (Group C).Methods: Anthropometric measurements (height, body weight) were taken for all participants along with baseline values of hormonal parameters and bone ...